Medication 7-351 - Etomidate (Amidate)

CMH EMS & MIH Protocols

Scope of Practice:

• Registered Nurse
• Paramedic
• Community Paramedic

Route(s):

• IO, IV,

Pharmacodynamics (class and mechanism of action):

• Sedative, non-barbiturate hypnotic (Unknown GABA-like effects. No analgesic effects. Has few cardiovascular or respiratory effects. Cerebro-protective: Decreases ICP and IOP.).

Pharmacokinetics:

• Half-life: 75 minutes.
• Onset time: 30-60 seconds.
• Peak action time: 1 minute.
• Duration of action: 3-5 minutes.

• Peak	24	48	72	96	120	144	168	192	216	240	264	seconds
  Duration	24	48	72	96	120	144	168	192	216	240	264	seconds

Dosing:

• Refer to specific protocol(s) below for dose(s).

Indications:

• Protocol 2-044 - Airway: RSI.
• Protocol 2-660 - Pain Control.
• Equipment 8-108 - Cardiac Monitor.

Contraindications:

• Hypersensitivity.

Pregnancy Risk Factor:

• Category C
• Risk not ruled out: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. FDA requires a relatively large amount of high-quality data on a pharmaceutical for it to be defined as Pregnancy Category A. As a result of this, many drugs that would be considered Pregnancy Category A in other countries are allocated to Category C by the FDA.

Potential Incompatibilities:

• NA.

Precautions and Adverse Effects:

• Use with caution in patients with Sepsis.
• Single dose only.
• May cause marked hypotension, Severe Asthma, myoclonic skeletal muscle movements, Apnea, Hypertension, dysrhythmias, Nausea, Vomiting, hiccups, snoring, adrenal insufficiency, laryngospasm, and/or cardiac arrhythmias.

Antidote:

• NA.

Controlled Substance Information:

• Not a scheduled drug
• The DEA and FDA have not identified this drug with a schedule classification.
• DEA number: NA.
• Narcotic: No.
• Street names: NA.

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Polk, Hickory, Cedar, & St Clair County EMS Protocols is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.